The Hedgehog (Hh) family of proteins control cell growth, survival, and fate, and pattern
almost every aspect of the vertebrate body plan. The use of a single morphogen for such a …

The cochlea, a coiled structure located in the ventral region of the inner ear, acts as the
primary structure for the perception of sound. Along the length of the cochlear spiral is the …

Cranial placodes are specialized regions of the ectoderm, which give rise to various sensory
ganglia and contribute to the pituitary gland and sensory organs of the vertebrate head …

The sensory epithelia of the inner ear contain mechanosensory hair cells and non-sensory
supporting cells. Both classes of cell are heterogeneous, with phenotypes varying both …

The inner ear is one of the most morphologically elaborate tissues in vertebrates, containing
a group of mechanosensitive sensory organs that mediate hearing and balance. These …

Foliation of the mouse cerebellum occurs primarily during the first 2 weeks after birth and is
accompanied by tremendous proliferation of granule cell precursors (GCPs). We have …

The inner ear is a structurally complex vertebrate organ built to encode sound, motion, and
orientation in space. Given its complexity, it is not surprising that inner ear dysfunction is a …

The cerebellum consists of a highly organized set of folia that are largely generated
postnatally during expansion of the granule cell precursor (GCP) pool. Since the secreted …

The inner ear is partitioned along its dorsal/ventral axis into vestibular and auditory organs,
respectively. Gene expression studies suggest that this subdivision occurs within the otic …

The otic placode, the anlagen of the inner ear, develops from an ectodermal field
characterized by expression of the transcription factor Pax2. Previous fate mapping studies …