The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type
II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in …

Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR). It
plays a main role in the calcium homeostasis and metabolism. In addition, vitamin D display …

Bone marrow vascular niches sustain hematopoietic stem cells (HSCs) and are drastically
remodeled in leukemia to support pathological functions. Acute myeloid leukemia (AML) …

Host microbiota crosstalk is essential for the production and functional modulation of blood-
cell lineages. Whether, and if so how, the microbiota influences hematopoietic stem cells …

The concept of differentiation therapy emerged from the fact that hormones or cytokines may
promote differentiation ex vivo, thereby irreversibly changing the phenotype of cancer cells …

Cancer is among the leading causes of death worldwide. Although a number of new
treatment options have been developed in recent years, there remains a need for improved …

Mutations in the IDH1 and IDH2 genes encoding isocitrate dehydrogenases are frequently
found in human glioblastomas and cytogenetically normal acute myeloid leukaemias (AML) …

Cancer cells require nutrients and energy to adapt to increased biosynthetic activity, and
protein synthesis inhibition downstream of mammalian target of rapamycin complex 1 …

Iron, an indispensable element for life, is involved in all kinds of important physiological
activities. Iron promotes cell growth and proliferation, but it also causes oxidative stress …

As 2 O 3 cures acute promyelocytic leukemia (APL) by initiating PML/RARA oncoprotein
degradation, through sumoylation of its PML moiety. However, how As 2 O 3 initiates PML …