It has been over 50 years since a review has focused exclusively on the monoamine
oxidase (MAO) inhibitor tranylcypromine (TCP). A new review has therefore been conducted …

Genome-wide association studies (GWAS) have revealed multiple genomic loci conferring
risk of bipolar disorder (BD), providing hints for its underlying pathobiology. However, there …

Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that has antidepressant-
like effects in animal models and may be implicated in the etiology of mood-related …

Variants within the monoamine oxidase A (MAO-A, MAOA) and tryptophan hydroxylase 2
(TPH2) genes, the main enzymes in cerebral serotonin (5-HT) turnover, affect risk for …

The dopamine hypothesis of schizophrenia posits that increased subcortical dopamine
underpins psychosis. In vivo imaging studies indicate an increased presynaptic dopamine …

Antidepressant medications are the most common treatment for major depression and
related disorders. Pharmacogenetic studies have demonstrated that response to these …

Genome-wide association studies (GWASs) have revealed substantial genetic components
comprised of single nucleotide polymorphisms (SNPs) in the heritable risk of psychiatric …

Background Neuroticism is associated with low emotional stability, and it is characterized by
a tendency to perceive ordinary situations as threatening and difficult to manage. This …

Monoamine oxidase A (MAOA), a mitochondrial enzyme, is closely associated with
neurological disorders. Recently, MAOA has been linked to the progression of prostate …

Abstract Bipolar disorder (BPD), schizophrenia (SCZ) and unipolar major depressive
disorder (MDD) are primary psychiatric disorders sharing substantial genetic risk factors. We …