As exemplified particularly with vasopressin and oxytocin, release of neuropeptides within
the brain occurs from dendrites, somata, and axons of neurosecretory neurons; mechanisms …

Metabotropic glutamate receptors (mGlus) are a family of G-protein-coupled receptors
activated by the neurotransmitter glutamate. Molecular cloning has revealed eight different …

Analysis of excitatory synaptic transmission in the rat hypothalamic supraoptic nucleus
revealed that glutamate clearance and, as a consequence, glutamate concentration and …

Electrophysiological research on mGluRs is now very extensive, and it is clear that activation
of mGluRs results in a large number of diverse cellular actions. Studies of mGluRs and on …

Anxiety and stress disorders are the most commonly occurring of all mental illnesses, and
current treatments are less than satisfactory. So, the discovery of novel approaches to treat …

Movement, the fundamental component of behavior and the principal extrinsic action of the
brain, is produced when skeletal muscles contract and relax in response to patterns of action …

Glutamate acts on postsynaptic glutamate receptors to mediate excitatory communication
between neurons. The discovery that additional presynaptic glutamate receptors can …

Extracellular glutamate of glial origin modulates glial and neuronal glutamate release and
synaptic plasticity. Estimates of the tonic basal concentration of extracellular glutamate …

Local inhibitory synaptic inputs to neurons of the rat hypothalamic paraventricular nucleus
(PVN) were studied by using glutamate microstimulation and conventional intracellular and …

Oxytocin secretion from the posterior pituitary gland is increased during parturition,
stimulated by the uterine contractions that forcefully expel the fetuses. Since oxytocin …