Neuropathic pain: a maladaptive response of the nervous system to damage

M Costigan, J Scholz, CJ Woolf - Annual review of neuroscience, 2009 - annualreviews.org
Neuropathic pain is triggered by lesions to the somatosensory nervous system that alter its
structure and function so that pain occurs spontaneously and responses to noxious and …

Efficacy of antidepressants as analgesics: a review

P Dharmshaktu, V Tayal… - The Journal of Clinical …, 2012 - Wiley Online Library
Persistent pain disorders are usually not adequately alleviated by nonsteroidal anti‐
inflammatory drugs or other simple analgesics. Use of antidepressants as adjuvant therapy …

Antibodies and venom peptides: new modalities for ion channels

H Wulff, P Christophersen, P Colussi… - Nature Reviews Drug …, 2019 - nature.com
Ion channels play fundamental roles in both excitable and non-excitable tissues and
therefore constitute attractive drug targets for myriad neurological, cardiovascular and …

TNF-alpha contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2

L Zhang, T Berta, ZZ Xu, T Liu, JY Park, RR Ji - Pain, 2011 - journals.lww.com
Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory cytokine. It is generally
believed that TNF-α exerts its effects primarily via TNF receptor subtype-1 (TNFR1). We …

Antidepressants for the treatment of chronic pain

B Verdu, I Decosterd, T Buclin, F Stiefel, A Berney - Drugs, 2008 - Springer
Chronic pain represents one of the most important public health problems and, in addition to
classical analgesics, antidepressants are an essential part of the therapeutic strategy. This …

Intracellular signaling in primary sensory neurons and persistent pain

JK Cheng, RR Ji - Neurochemical research, 2008 - Springer
During evolution, living organisms develop a specialized apparatus called nociceptors to
sense their environment and avoid hazardous situations. Intense stimulation of high …

Long noncoding RNA (lncRNA): a target in neuropathic pain

S Wu, J Bono, YX Tao - Expert opinion on therapeutic targets, 2019 - Taylor & Francis
Introduction: Current treatments for neuropathic pain are limited in part due to the incomplete
understanding of its underlying mechanisms. Recent evidence reveals the dysregulated …

Tetrodotoxin (TTX) as a therapeutic agent for pain

FR Nieto, EJ Cobos, MÁ Tejada… - Marine drugs, 2012 - mdpi.com
Tetrodotoxin (TTX) is a potent neurotoxin that blocks voltage-gated sodium channels
(VGSCs). VGSCs play a critical role in neuronal function under both physiological and …

TNF-α contributes to up-regulation of Nav1. 3 and Nav1. 8 in DRG neurons following motor fiber injury

XH He, Y Zang, X Chen, RP Pang, JT Xu, X Zhou… - Pain, 2010 - journals.lww.com
A large body of evidence has demonstrated that the ectopic discharges of action potentials
in primary afferents, resulted from the abnormal expression of voltage gated sodium …

miR-7a alleviates the maintenance of neuropathic pain through regulation of neuronal excitability

A Sakai, F Saitow, N Miyake, K Miyake, T Shimada… - Brain, 2013 - academic.oup.com
Neuronal damage in the somatosensory system causes intractable chronic neuropathic
pain. Plastic changes in sensory neuron excitability are considered the cellular basis of …