Cellular senescence is a permanent state of cell cycle arrest that occurs in proliferating cells
subjected to different stresses. Senescence is, therefore, a cellular defense mechanism that …

The function of vascular endothelial growth factor (VEGF) in cancer is not limited to
angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells …

Chronic inflammation and an immunosuppressive microenvironment promote prostate
cancer (PCa) progression and diminish the response to immune checkpoint blockade (ICB) …

The prostate gland consists of basal and luminal cells arranged as pseudostratified
epithelium. In tissue recombination models, only basal cells reconstitute a complete prostate …

The level of SETD2-mediated H3K36me3 is inversely correlated with that of EZH2-catalyzed
H3K27me3. Nevertheless, it remains unclear whether these two enzymatic activities are …

How cancer cells acquire the competence to colonize distant organs remains a central
question in cancer biology. Tumors can release large numbers of cancer cells into the …

Arteries and veins are specified by antagonistic transcriptional programs. However, during
development and regeneration, new arteries can arise from pre-existing veins through a …

Abstract In the United States, prostate cancer (PCa) is the most commonly diagnosed non-
cutaneous cancer in males and the second leading cause of cancer-related death for men …

The transforming growth factor (TGF)-β and phosphoinositide 3-kinase/protein kinase B
(PI3K/AKT) signaling pathways are used in cells to control numerous responses, including …

Prostate cancer (PCa) is a leading cause of cancer-related death of men globally. Since its
introduction, there has been intense debate as to the effectiveness of the prostate specific …