Human viral oncogenesis is a complex phenomenon and a major contributor to the global
cancer burden. Several recent findings revealed cellular and molecular pathways that …

Abstract P-glycoprotein (P-gp), multiple drug resistance associated proteins (MRPs), and
cytochrome P450 3A4 together constitute a highly efficient barrier for many orally absorbed …

HIV-infected individuals usually receive a wide variety of drugs in addition to their
antiretroviral drug regimen. Since both non-nucleoside reverse transcriptase inhibitors and …

Fosamprenavir is one of the most recently approved HIV-1 protease inhibitors (Pis) and
offers reductions in pill number and pill size, and omits the need for food and fluid …

Macrolides are characterised by their basic structure which is made up of a lactonic cycle
with 2 osidic chains. They are classified according to the number of carbon atoms in the …

As millions of patients with HIV/AIDS are put on treatment with the highly active antiretroviral
therapy (HAART), drug interactions have become a major concern for healthcare providers …

Like any other drug, antimicrobial drugs are prone to pharmacokinetic drug interactions.
These drug interactions are a major concern in clinical practice as they may have an effect …

Objective To evaluate the relationship between the acute inflammatory response after
surgical trauma and changes in hepatic cytochrome P450 3A4 activity, compare changes in …

The objective of this study was to determine if there is a pharmacokinetic interaction when
amprenavir is given with rifabutin or rifampin and to determine the effects of these drugs on …

More than 20 individual and fixed-dose combinations of antiretrovirals are approved for the
treatment of human immunodeficiency virus (HIV) infection. However, owing to the ongoing …