Congenital hearing loss (hearing loss that is present at birth) is one of the most prevalent
chronic conditions in children. In the majority of developed countries, neonatal hearing …

Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This
progressive hearing impairment leads to social isolation and is also associated with …

Much is known about the mechanotransducer (MT) channels mediating transduction in hair
cells of the vertrbrate inner ear. With the use of isolated preparations, it is experimentally …

Sound pressure fluctuations striking the ear are conveyed to the cochlea, where they vibrate
the basilar membrane on which sit hair cells, the mechanoreceptors of the inner ear …

Cells use the actin cytoskeleton for many of their functions, including their division,
adhesion, mechanosensing, endo-and phagocytosis, migration, and invasion. Actin bundles …

Background Recent studies in a variety of animal models including rodents, monkeys, and
humans suggest that transcranial focused ultrasound (tFUS) has considerable promise for …

Inner ear hair cells (HCs) detect sound through the deflection of mechanosensory
stereocilia. Stereocilia are inserted into the cuticular plate of HCs by parallel actin rootlets …

Inner ear hair cells detect sound through deflection of stereocilia, the microvilli-like
projections that are arranged in rows of graded heights. Calcium and integrin-binding …

Background Nanoinjection—the process of intracellular delivery using vertically configured
nanostructures—is a physical route that efficiently negotiates the plasma membrane, with …

This short review aims at revisiting some of the putative mechanisms of tinnitus. Cochlear-
type tinnitus is suggested to result from aberrant activity generated before or at the cochlear …