Male-female differences in many developmental mechanisms lead to the formation of two
morphologically and physiologically distinct sexes. Although this is expected for traits with …

Background Obesity is a top public health problem associated with an increase in colorectal
cancer incidence. Stem cells are the chief cells in tissue homeostasis that self-renew and …

A high‑fat diet (HFD) or obesity‑promoting diet is closely associated with metabolic diseases
and intestinal tumors, particularly in middle‑aged individuals (typically 45‑64 years old). The …

Background Sex differences in experimental stroke outcomes are well documented, such
that adult males have a greater infarct volume, increased stroke-induced mortality, and more …

Abstract Purpose The Sex Differences in Radiation Research workshop addressed the role
of sex as a confounder in radiation research and its implication in real-world radiological …

Abstract Representation of humans from diverse backgrounds in the drug development
process is key to advancing health equity, and while clinical trial design has recently made …

The introduction of sex-as-a-biological-variable policies at funding agencies around the
world has led to an explosion of very recent observations of sex differences in the biology …

Tissue radiosensitivity plays a critical role in the overall outcome of radiation therapy.
Identifying characteristics that predict how a patient may respond to radiotherapy enables …

The impaired mucosal barrier is a hallmark of ulcerative colitis (UC), an inflammatory colonic
disorder with epidemiological and pathophysiology sex bias. UC Patients overexpress the …

Sex differences in physiology are noted in clinical and animal studies. However,
mechanisms underlying these observed differences between males and females remain …