Abstract Purpose of Review We review non-pharmacological and pharmacological
approaches to managing behavioral and psychological symptoms of dementia (BPSD). We …

Apathy is a common condition that involves diminished initiative, diminished interest and
diminished emotional expression or responsiveness. It is highly prevalent in the context of a …

Importance Apathy, characterized by diminished will or initiative and one of the most
prevalent neuropsychiatric symptoms in individuals with Alzheimer disease, is associated …

Type 2 diabetes mellitus (T2DM) is associated with depressive symptoms, and comorbid
depression in those with T2DM has been associated with adverse clinical profiles …

Early and progressive dysfunctions of the dopaminergic system from the Ventral Tegmental
Area (VTA) have been described in Alzheimer's Disease (AD). During the long pre …

Highlights•Apathy is the commonest neuropsychiatric symptom in Alzheimer's disease
(AD).•Neuroimaging findings implicate frontostriatal circuits involving the anterior cingulate …

Background Despite the high prevalence of apathy in Alzheimer's disease (AD), and its
harmful effects, there are currently no therapies proven to treat this symptom. Recently, a …

Apathy is a common and disabling behavioral concomitant of many neurodegenerative
conditions. The presence of apathy with Mild Cognitive Impairment (MCI) is linked with …

Background Dysfunction of the locus coeruleus-noradrenergic system occurs early in
Alzheimer's disease, contributing to cognitive and neuropsychiatric symptoms in some …

Apathy is one of the most prevalent, stable and persistent neuropsychiatric symptom across
the neurocognitive disorders spectrum. Recent advances in understanding of …