The rodent hippocampus generates new neurons throughout life. This process, named adult
hippocampal neurogenesis (AHN), is a striking form of neural plasticity that occurs in the …

Of the neurogenic zones in the adult brain, adult hippocampal neurogenesis attracts the
most attention, because it is involved in higher cognitive function, most notably memory …

Cognitive dysfunction and reactive microglia are hallmarks of traumatic brain injury (TBI), yet
whether these cells contribute to cognitive deficits and secondary inflammatory pathology …

Status epilepticus (SE), a medical emergency that is typically terminated through
antiepileptic drug treatment, leads to hippocampus dysfunction typified by …

The protective/neurotoxic role of fractalkine (CX3CL1) and its receptor CX3C chemokine
receptor 1 (CX3CR1) signaling in neurodegenerative disease is an intricate and highly …

Alzheimer's disease (AD) is characterized by cognitive impairment, progressive
neurodegeneration and formation of amyloid-β (Aβ)-containing plaques and neurofibrillary …

Background Essentially all knowledge about adult hippocampal neurogenesis in humans
still comes from one seminal study by Eriksson et al. in 1998, although several others have …

Neural stem cells in various regions of the vertebrate brain continuously generate neurons
throughout life,,,. In the mammalian hippocampus, a region important for spatial and …

Progress in the field of neurogenesis is currently limited by the lack of tools enabling fast and
quantitative analysis of neurogenesis in the adult brain. Doublecortin (DCX) has recently …

Establishing the cellular identity in vivo of adult multipotent neural progenitors is
fundamental to understanding their biology. We used two transgenic strategies to determine …