Potential pitfalls of using fractional anisotropy, axial diffusivity, and radial diffusivity as biomarkers of cerebral white matter microstructure

CR Figley, MN Uddin, K Wong, J Kornelsen… - Frontiers in …, 2022 - frontiersin.org
Fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD) are commonly
used as MRI biomarkers of white matter microstructure in diffusion MRI studies of …

Diffusion MRI fiber tractography of the brain

B Jeurissen, M Descoteaux, S Mori… - NMR in …, 2019 - Wiley Online Library
The ability of fiber tractography to delineate non‐invasively the white matter fiber pathways
of the brain raises possibilities for clinical applications and offers enormous potential for …

[HTML][HTML] Investigating white matter fibre density and morphology using fixel-based analysis

DA Raffelt, JD Tournier, RE Smith, DN Vaughan… - Neuroimage, 2017 - Elsevier
Voxel-based analysis of diffusion MRI data is increasingly popular. However, most white
matter voxels contain contributions from multiple fibre populations (often referred to as …

Multi-tissue constrained spherical deconvolution for improved analysis of multi-shell diffusion MRI data

B Jeurissen, JD Tournier, T Dhollander, A Connelly… - NeuroImage, 2014 - Elsevier
Constrained spherical deconvolution (CSD) has become one of the most widely used
methods to extract white matter (WM) fibre orientation information from diffusion-weighted …

Anatomical accuracy of brain connections derived from diffusion MRI tractography is inherently limited

C Thomas, FQ Ye, MO Irfanoglu… - Proceedings of the …, 2014 - National Acad Sciences
Tractography based on diffusion-weighted MRI (DWI) is widely used for mapping the
structural connections of the human brain. Its accuracy is known to be limited by technical …

Investigating the prevalence of complex fiber configurations in white matter tissue with diffusion magnetic resonance imaging

B Jeurissen, A Leemans, JD Tournier… - Human brain …, 2013 - Wiley Online Library
It has long been recognized that the diffusion tensor model is inappropriate to characterize
complex fiber architecture, causing tensor‐derived measures such as the primary …

[HTML][HTML] Diffusion tensor imaging and beyond

JD Tournier, S Mori, A Leemans - Magnetic resonance in medicine, 2011 - ncbi.nlm.nih.gov
The diffusion of water molecules inside organic tissues is often anisotropic (1). Namely, if
there are aligned structures in the tissue, the apparent diffusion coefficient (ADC) of water …

The basis of anisotropic water diffusion in the nervous system–a technical review

C Beaulieu - NMR in Biomedicine: An International Journal …, 2002 - Wiley Online Library
Anisotropic water diffusion in neural fibres such as nerve, white matter in spinal cord, or
white matter in brain forms the basis for the utilization of diffusion tensor imaging (DTI) to …

Apparent fibre density: a novel measure for the analysis of diffusion-weighted magnetic resonance images

D Raffelt, JD Tournier, S Rose, GR Ridgway… - Neuroimage, 2012 - Elsevier
This article proposes a new measure called Apparent Fibre Density (AFD) for the analysis of
high angular resolution diffusion-weighted images using higher-order information provided …

Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolution

JD Tournier, F Calamante, A Connelly - Neuroimage, 2007 - Elsevier
Diffusion-weighted (DW) MR images contain information about the orientation of brain white
matter fibres that potentially can be used to study human brain connectivity in vivo using …