Ratiometric fluorescent probes allow the simultaneous measurement of two fluorescence
signals at different wavelengths followed by calculation of their intensity ratio, which can …

Membrane proteins mediate a number of cellular functions and are associated with several
diseases and also play a crucial role in pathogenicity. Due to their importance in cellular …

Exogenous substances like drugs, when absorbed, enter into the circulatory system and
bind reversibly and extensively to human serum albumin (HSA). But transport of various …

Pore-forming peptides are of high biological relevance particularly as cytotoxic agents, but
their properties are also applicable for the permeabilization of lipid membranes for …

Dynamics of confined water has interesting implications in the organization and function of
molecular assemblies such as membranes. A direct consequence of this type of …

Peptide–membrane interactions have been gaining increased relevance, mainly in
biomedical investigation, as the potential of the natural, nature-based and synthetic peptides …

We performed, using an all-atom force field, molecular dynamics computer simulations to
study the binding of melittin to the POPC bilayer and its subsequent reorientation in this …

The structural organization and dynamic nature of the biomembrane components are
important determinants for numerous cellular functions. Particularly, membrane proteins are …

Monitoring insertion and orientation of peptides in situ on cell membranes remains a
challenge. To this end, we synthesized an l-amino acid (AFaa) containing a dual …

Antibody–drug conjugates (ADCs) are an established modality for the tissue-specific
delivery of chemotherapeutics. However, due to the hydrophobic nature of many cytotoxic …