In response to the energy demand triggered by developmental signals and environmental
stressors, the cells launch the mitochondrial biogenesis process. This is a self‐renewal …

Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycaemia,
with absolute insulin deficiency or insulin resistance as the main cause, and causes damage …

Metformin can suppress gluconeogenesis and reduce blood sugar by activating adenosine
monophosphate-activated protein kinase (AMPK) and inducing small heterodimer partner …

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …

The AMPK/PGC-1α pathway-mediated mitochondrial dysfunction has been supposed to
play a crucial role in pathogenesis of diabetic peripheral neuropathy (DPN). The present …

Today, pharmacognosy is considered a valuable science in the prevention and treatment of
diseases. Among herbals, Berberine is an isoquinoline alkaloid found in the Berberis …

Honokiol is a phytochemical component with a variety of pharmacological properties.
However, the major limitation of Honokiol is its poor solubility and low oral bioavailability. In …

Since the beginning of the 21st century, studies have focused on developing drugs from
naturally occurring compounds. Berberine (Brb) as a plant‐derived compound is of interest …

Berberine is a natural active ingredient extracted from the rhizome of Rhizoma Coptidis,
which interacts with multiple intracellular targets and exhibits a wide range of …

Abstract Piceatannol (PCN), a SIRT1 activator, regulates multiple oxidative stress
mechanism and has anti-inflammatory potential in various inflammatory conditions …