Mitochondria in health, disease, and aging

JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Defective mitophagy in Alzheimer's disease

JA Pradeepkiran, PH Reddy - Ageing Research Reviews, 2020 - Elsevier
Alzheimer's disease (AD) is a progressive, mental illness without cure. Several years of
intense research on postmortem AD brains, cell and mouse models of AD have revealed …

Mitochondria and mitochondrial cascades in Alzheimer's disease

RH Swerdlow - Journal of Alzheimer's Disease, 2018 - content.iospress.com
Decades of research indicate mitochondria from Alzheimer's disease (AD) patients differ
from those of non-AD individuals. Initial studies revealed structural differences, and …

Amyloid beta and phosphorylated tau-induced defective autophagy and mitophagy in Alzheimer's disease

PH Reddy, DMA Oliver - Cells, 2019 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
memory loss and multiple cognitive impairments. Several decades of intense research have …

Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse

H Morton, S Kshirsagar, E Orlov, LE Bunquin… - Free Radical Biology …, 2021 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
memory loss and multiple cognitive impairments. AD is marked by multiple cellular changes …

[HTML][HTML] Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ …

Z He, X Li, Z Wang, Y Cao, S Han, N Li, J Cai, S Cheng… - Redox Biology, 2023 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by the
deposition of β-amyloid (Aβ) peptides and dysfunction of mitochondrion, which result in …

Defective autophagy and mitophagy in aging and Alzheimer's disease

M Tran, PH Reddy - Frontiers in neuroscience, 2021 - frontiersin.org
Aging is the time-dependent process that all living organisms go through characterized by
declining physiological function due to alterations in metabolic and molecular pathways …

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

MT Lin, MF Beal - Nature, 2006 - nature.com
Many lines of evidence suggest that mitochondria have a central role in ageing-related
neurodegenerative diseases. Mitochondria are critical regulators of cell death, a key feature …

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease …

M Manczak, MJ Calkins, PH Reddy - Human molecular genetics, 2011 - academic.oup.com
The purpose of our study was to better understand the relationship between mitochondrial
structural proteins, particularly dynamin-related protein 1 (Drp1) and amyloid beta (Aβ) in the …

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

X Wang, BO Su, H Lee, X Li, G Perry… - Journal of …, 2009 - Soc Neuroscience
Mitochondrial dysfunction is a prominent feature of Alzheimer's disease (AD) neurons. In this
study, we explored the involvement of an abnormal mitochondrial dynamics by investigating …