Parkinson's disease is characterized by the loss of nigrostriatal dopaminergic signaling and
the presence of alpha-synuclein aggregates (also called Lewy bodies and neurites) …

Parkinson's disease (PD) is an adult onset neurodegenerative disease that is characterized
by selective degeneration of neurons primarily in the substantia nigra. At present, the …

Parkinson's disease is a progressive neuropathological disorder that belongs to the class of
synucleinopathies, in which the protein alpha-synuclein is found at abnormally high …

Propagation of α-synuclein aggregates has been suggested as a contributing factor in
Parkinson's disease (PD) progression. However, the molecular mechanisms underlying α …

Synucleinopathies, including Parkinson's disease (PD), dementia with Lewy Bodies (DLB),
and multiple system atrophy (MSA), are characterized by the misfolding and subsequent …

Parkinson's disease (PD) is a multifactorial disorder involving both motor and non-motor
symptoms caused by the progressive death of distinct neuronal populations, including …

Several age-related neurodegenerative disorders are characterized by the deposition of
aberrantly folded endogenous proteins. These proteins have prion-like propagation and …

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are neurodegenerative
disorders characterized by the misfolding and aggregation of alpha-synuclein (aSyn) …

Background Parkinson's disease is a disabling neurodegenerative movement disorder
characterized by dopaminergic neuron loss induced by α-synuclein oligomers. There is an …

Parkinson's Disease (PD) is the second-most common neurodegenerative disease in the
world, yet the fundamental and underlying causes of the disease are largely unknown, and …