Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

Adipogenesis, osteogenesis and chondrogenesis of human mesenchymal stem/stromal
cells (MSC) are complex and highly regulated processes. Over the years, several studies …

Translation control is critical to regulate protein expression. By directly adjusting protein
levels, cells can quickly respond to dynamic transitions during stem cell differentiation and …

Despite their burden, most congenital defects remain poorly understood, due to lack of
knowledge of embryological mechanisms. Here, we identify Greb1l mutants as a mouse …

Although differential transcription drives the development of multicellular organisms, the
ultimate readout of a protein-coding gene is ribosome-dependent mRNA translation …

Defining the mechanisms that govern heart development is essential for identifying the
etiology of congenital heart disease. Here, quantitative proteomics was used to measure …

Like all other parts of the central nervous system, the mammalian neocortex undergoes
temporally ordered set of developmental events, including proliferation, differentiation …

Pluripotent stem cells (PSC) can be used as a model to study cardiomyogenic differentiation.
In vitro modeling can reproduce cardiac development through modulation of some key …

One of the features of pathological cardiac hypertrophy is enhanced translation and protein
synthesis. Translational inhibition has been shown to be an effective means of treating …

Alternative polyadenylation (APA) increases transcript diversity through the generation of
isoforms with varying 3′ untranslated region (3′ UTR) lengths. As the 3′ UTR harbors …