In the last decades, autoimmune diseases have experienced a dramatic increase in Western
countries. The involvement of environmental factors is strongly suspected to explain this rise …

OA is a degenerative joint disease characterized by articular cartilage degradation,
osteophyte formation, synovitis, and subchondral bone sclerosis. One of OAs main risk …

Metabolic osteoarthritis (OA) has now been characterized as a subtype of OA, and links
have been discovered between this phenotype and metabolic syndrome (MetS)—both with …

Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci,
ligaments and subchondral bone, and synovial inflammation. Biomarkers are being …

Metabolic syndrome (MetS) represents a cluster of metabolic and cardiovascular
complications, including obesity and visceral adiposity, insulin resistance, dyslipidemia …

Osteoarthritis (OA) is a heterogeneous disorder with several risk factors. Among them,
obesity has a major impact on both loading and non-loading joints. Mechanical overload …

INTRODUCTION: Osteoarthritis (OA) of the knee joint is caused by genetic and hormonal
factors and by inflammation, in combination with biomechanical alterations. It is …

Important advances in our understanding of the relationships between adipokines,
inflammation and the immune response have been achieved in the past 10 years. White …

Osteoarthritis (OA) is a common chronic joint disorder with a multifactorial etiology including
genetic and environmental factors. Metabolic triggered inflammation, induced by nutrient …

This article reviews the pathogenetic role of metabolic disorders, which are of paramount
relevance to the progression of tendon damage. In diabetes, the prevalence of …