Mycobacterium tuberculosis, the bacterium responsible for tuberculosis, is the global
leading cause of mortality from an infectious agent. Part of this success relies on the unique …

Highlights•Prodrugs are over-represented among hits from phenotypic
screens.•Hypomorphs are versatile tools for use in TB drug target validation.•Innovative …

In recent years, whole-cell-based screens for novel small molecule inhibitors active against
Mycobacterium tuberculosis in culture followed by the whole-genome sequencing of …

VCC234718, a molecule with growth inhibitory activity against Mycobacterium tuberculosis
(Mtb), was identified by phenotypic screening of a 15344-compound library. Sequencing of a …

Glycolipids are prominent components of bacterial membranes that play critical roles not
only in maintaining the structural integrity of the cell but also in modulating host-pathogen …

Trehalose biosynthesis is considered an attractive target for the development of
antimicrobials against fungal, helminthic and bacterial pathogens including Mycobacterium …

Although efforts to identify novel therapies for the treatment of tuberculosis have led to the
identification of several promising drug candidates, the identification of high-quality hits from …

Fold-switch pathways remodel the secondary structure topology of proteins in response to
the cellular environment. It is a major challenge to understand the dynamics of these folding …

All mycobacteria, including nontuberculous mycobacteria (NTM), synthesize an array of
lipids including phosphatidylinositol mannosides (PIM), lipomannan (LM), and …

Phosphatidyl‐myo‐inositol mannosyltransferase (Pim) is a subset of the Glycosyl
transferase type family that has been synthesized from 1D‐myo‐inositol and GDP‐α‐d …