PTEN is a phosphatase which metabolises PIP 3, the lipid product of PI 3-Kinase, directly
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …

Identifying putative biomarkers of clinical outcomes in cancer is crucial for successful
enrichment, and for the selection of patients who are the most likely to benefit from a specific …

Endometrial carcinoma has been traditionally divided into type 1 or endometrioid type that is
usually moderate to well differentiated and type 2 that is usually poorly differentiated with …

Mismatch repair (MMR) analysis in breast cancer may help to inform immunotherapy
decisions but it lacks breast-specific guidelines. Unlike in other neoplasms, MMR protein …

Purpose Endometrial cancer is the most common gynecological malignancy in developed
countries. The role of tumor suppressor genes (TSG) in endometrioid endometrial …

Tumor-suppressive effects of PTEN are well-known, but modern evidence suggest that they
are not limited to its ability to inhibit pro-oncogenic PI3K/AKT signaling pathway. Features of …

Endometrial carcinoma (ECa) is one of the most common neoplasia of the female genital
tract. The phosphatase and tensin (PTEN) homolog is the most frequently mutated tumor …

Endometrial cancer, also known as uterine cancer, is the most common gynaecological
malignancy with burgeoning incidence and mortality rates globally. Racial disparity …

Although the progressive histologic steps leading to endometrial cancer (EndoCA), the most
common female reproductive tract malignancy, from endometrial hyperplasia are well …

Endometrial cancers are mostly estrogen-dependent. FOXP1 is a P subfamily of forkhead
box (FOX), and known as an estrogen-responsive transcription factor. The aims of this study …