Circadian (∼ 24 h) clocks are self‐sustained endogenous oscillators with which organisms
keep track of daily and seasonal time. Circadian clocks frequently rely on interlocked …

With our growing awareness of the complexity underlying biological phenomena, our need
for computational models becomes increasingly apparent. Due to their properties, biological …

The suprachiasmatic nuclei (SCN), the central circadian pacemakers in mammals, comprise
a multiscale neuronal system that times daily events. We use recent advances in graphics …

Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We
report here that the suprachiasmatic nucleus (SCN) of Bmal1-null mutant mice …

We propose a novel, closed-loop approach to tuning deep brain stimulation (DBS) for
Parkinson's disease (PD). The approach, termed Phasic Burst Stimulation (PhaBS), applies …

To introduce this special issue on biological switches and clocks, we review the historical
development of mathematical models of bistability and oscillations in chemical reaction …

Highlights•Choice of modeling framework should account for experimental context and
data.•Accurate models offer biological insight and explain non-intuitive observations.•Multi …

Despite their complexity, biological systems are able to endure huge parameter fluctuations
and survive in the most diverse environmental conditions. Mathematical tools from graph …

Travel across multiple time zones results in desynchronization of environmental time cues
and the sleep–wake schedule from their normal phase relationships with the endogenous …

Circadian entrainment is necessary for rhythmic physiological functions to be appropriately
timed over the 24-hour day. Disruption of circadian rhythms has been associated with sleep …