Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …

Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA
mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of …

Lynch syndrome (LS) is characterised by predisposition to colorectal, endometrial, and other
cancers and is caused by inherited pathogenic variants affecting the DNA mismatch repair …

Lynch syndrome patients are susceptible to colorectal and endometrial cancers owing to
inactivating germline mutations in mismatch repair genes, including MSH2 (ref.). Here we …

Transgenerational epigenetic effects include all processes that have evolved to achieve the
nongenetic determination of phenotype. There has been a long-standing interest in this area …

In the early years of the molecular biology revolution, cancer research was mainly focused
on genetic changes (ie, those that altered DNA sequences). Although this has been …

DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-
frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within …

Endometriosis is a common gynecologic disorder with an enigmatic etiopathogenesis.
Although it has been proposed that endometriosis is a hormonal disease, an autoimmune …

Poulogiannis G, Frayling IM & Arends MJ (2010) Histopathology56, 167–179 DNA mismatch
repair deficiency in sporadic colorectal cancer and Lynch syndrome DNA mismatch repair …

Persons who have hypermethylation of one allele of MLH1 in somatic cells throughout the
body (a germ-line epimutation) have a predisposition for the development of cancer in a …