Fragile sites are heritable specific chromosome loci that exhibit an increased frequency of
gaps, poor staining, constrictions or breaks when chromosomes are exposed to partial DNA …

Through investigation of hemizygous and homozygous deletions in common human
cancers, including lung cancer, we have cloned and characterized a gene at chromosome …

The candidate tumor suppressor gene, FHIT, encompasses the common human
chromosomal fragile site at 3p14. 2, the hereditary renal cancer translocation breakpoint …

Allele loss and loss of expression of fragile histidine triad (FHIT), a putative tumor
suppressor gene located in chromosome region 3p14. 2, are frequent in several types of …

Triple-negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for
which no specific treatment is currently available. Although the retinoblastoma tumor …

Alteration of the FHIT (fragile histidine triad) gene occurs as an early and frequent event in
lung carcinogenesis. FHIT gene transfer into lung cancer cell line H460 lacking Fhit protein …

To determine whether the FHIT gene at 3p14. 2 is altered in head and neck squamous cell
carcinomas (HNSCC), we examined 26 HNSCC cell lines for deletions within the FHIT locus …

Although numerous studies have reported that high frequencies of loss of heterozygosity
(LOH) at various chromosomal arms have been identified in breast cancer, differential LOH …

▪ Abstract Common fragile sites form gaps at characteristic chromosome bands in
metaphases from normal cells after aphidicolin induction. The distribution of common fragile …

Chromosomal abnormalities, including homozygous deletions and loss of heterozygosity,
are among the most common features of human tumours. The short arm of human …