Fluorine does not belong to the pool of chemical elements that nature uses to build organic
matter. However, chemists have exploited the unique properties of fluorine and produced …

Fluorine-containing amino acids are becoming increasingly prominent in new drugs due to
two general trends in the modern pharmaceutical industry. Firstly, the growing acceptance of …

Alkylations of chiral or achiral Ni (II) complexes of glycine Schiff bases constitute a landmark
in the development of practical methodology for asymmetric synthesis of α-amino acids …

Direct α‐functionalization of NH2‐free glycinates with relatively weak electrophiles such as
α, β‐unsaturated esters still remains a big challenge in organic synthesis. With chiral …

This review provides a comprehensive treatment of literature data dealing with asymmetric
synthesis of α-amino-β-hydroxy and α, β-diamino acids via homologation of chiral Ni (II) …

The major goal of this review is a critical discussion of the literature data on asymmetric
synthesis of α-amino acids via Michael addition reactions involving Ni (II)-complexes of …

Abstract Development of synthetic methodology for preparation of enantiomerically pure
fluorine containing amino acids (FAAs) is one of the most actively pursued areas of …

The first chemical method for resolution of N, C‐unprotected β‐amino acids was developed
through enantioselective formation and disassembly of nickel (II) complexes under …

Naturally occurring compounds containing a CF bond are extremely rare; only a handful of
fluorine-containing carboxylic acids have been described so far. By contrast, man-made …

This report provides an overview of the practical methods for preparing symmetrically α, α-
disubstituted α-amino acids and their derivatives. Despite the growing application of this …