Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the isoenzymes COX-1 and COX-2 of
cyclooxygenase (COX). Renal side effects (eg, kidney function, fluid and urinary electrolyte …

When the kidney is subjected to acute increases in blood pressure (BP), renal blood flow
(RBF) and glomerular filtration rate (GFR) are observed to remain relatively constant. Two …

Macula densa cells in the distal nephron, according to the classic paradigm, are salt sensors
that generate paracrine chemical signals in the juxtaglomerular apparatus to control vital …

In adult mammalian kidney, cyclooxygenase-2 (COX-2) expression is found in a restricted
subpopulation of cells. The two sites of renal COX-2 localization detected in all species to …

Macula densa cells are unique renal biosensor cells that detect changes in luminal NaCl
concentration ([NaCl] L) and transmit signals to the mesangial cell/afferent arteriolar …

Tissue regeneration is limited in several organs, including the kidney, contributing to the
high prevalence of kidney disease globally. However, evolutionary and physiological …

Acute kidney injury (AKI) is a major public health problem that complicates 10–40% of
hospital admissions. Importantly, AKI is independently associated with increased risk of …

Olfactory-like chemosensory signaling occurs outside of the olfactory epithelium. We find
that major components of olfaction, including olfactory receptors (ORs), olfactory-related …

Ion cotransporters, such as the Na+/Cl− cotransporter (NCC), control renal salt re-absorption
and are regulated by the WNK-signalling pathway, which is over-stimulated in patients …

Among the environmental factors that affect blood pressure, dietary sodium chloride has
been studied the most, and there is general consensus that increased sodium chloride …