Melittin-based nano-delivery systems for cancer therapy

A Wang, Y Zheng, W Zhu, L Yang, Y Yang, J Peng - Biomolecules, 2022 - mdpi.com
Melittin (MEL) is a 26-amino acid polypeptide with a variety of pharmacological and
toxicological effects, which include strong surface activity on cell lipid membranes, hemolytic …

Pharmacological effects and mechanisms of bee venom and its main components: Recent progress and perspective

P Shi, S Xie, J Yang, Y Zhang, S Han, S Su… - Frontiers in …, 2022 - frontiersin.org
Bee venom (BV), a type of defensive venom, has been confirmed to have favorable
activities, such as anti-tumor, neuroprotective, anti-inflammatory, analgesic, anti-infectivity …

Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies

O Kutkat, Y Moatasim, AA Al‐Karmalawy… - Scientific Reports, 2022 - nature.com
During the current coronavirus disease 2019 (COVID-19) pandemic, symptoms of
depression are commonly documented among both symptomatic and asymptomatic …

Newly synthesized series of oxoindole–oxadiazole conjugates as potential anti-SARS-CoV-2 agents: In silico and in vitro studies

RM El-Masry, AA Al-Karmalawy, R Alnajjar… - New Journal of …, 2022 - pubs.rsc.org
In this study, a series of 1, 3, 4-oxadiazoles carrying the isatin moiety (IVa–g) as anti-SARS-
CoV-2 agents were designed and synthesized. Molecular docking of the compounds (IVa–g) …

Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2

K Gao, R Wang, J Chen, L Cheng, J Frishcosy… - Chemical …, 2022 - ACS Publications
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …

Strong inhibitory activity and action modes of synthetic maslinic acid derivative on highly pathogenic coronaviruses: COVID-19 drug candidate

R Soltane, A Chrouda, A Mostafa, AA Al-Karmalawy… - Pathogens, 2021 - mdpi.com
In late December 2019, a novel coronavirus, namely severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), escaped the animal–human interface and emerged as an …

Gramicidin S and melittin: Potential anti-viral therapeutic peptides to treat SARS-CoV-2 infection

MG Enayathullah, Y Parekh, S Banu, S Ram… - Scientific Reports, 2022 - nature.com
The COVID19 pandemic has led to multipronged approaches for treatment of the disease.
Since de novo discovery of drugs is time consuming, repurposing of molecules is now …

The current landscape of the antimicrobial peptide melittin and its therapeutic potential

HQ Zhang, C Sun, N Xu, W Liu - Frontiers in Immunology, 2024 - frontiersin.org
Melittin, a main component of bee venom, is a cationic amphiphilic peptide with a linear α-
helix structure. It has been reported that melittin can exert pharmacological effects, such as …

Updating the use of nano-biosensors as promising devices for the diagnosis of coronavirus family members: A systematic review

A Aquino, VMF Paschoalin, LLG Tessaro… - … of Pharmaceutical and …, 2022 - Elsevier
Coronavidae viruses, such as SARS-CoV, SARS-CoV-2, and MERS-CoV, cause severe
lower respiratory tract infection, acute respiratory distress syndrome and extrapulmonary …

[HTML][HTML] Antiviral polysaccharide and antiviral peptide delivering nanomaterials for prevention and treatment of SARS-CoV-2 caused COVID-19 and other viral …

S Homaeigohar, X Liu, M Elbahri - Journal of Controlled Release, 2023 - Elsevier
Antiviral peptides and antiviral polysaccharides can play a major role in the prevention and
treatment of emerging viral health problems. These antiviral compounds are biocompatible …