Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and
proliferation. As such, most human cancers differ from normal counterpart tissues by a …

The deregulation of the MYC family of oncogenes, including c-MYC, MYCN and MYCL
occurs in many types of cancers, and is frequently associated with a poor prognosis. The …

The proto-oncogene c-Myc regulates multiple biological processes mainly through
selectively activating gene expression. However, the mechanisms underlying c-Myc …

Background and Aims HCC is a leading cause of cancer‐related deaths globally with poor
outcome and limited therapeutic options. Although the myelocytomatosis (MYC) oncogene is …

Medulloblastoma (MB) is the most common malignant central nervous system tumor in
pediatric patients. Mainstay of therapy remains surgical resection followed by craniospinal …

A remarkable post-transitional modification of both histones and non-histone proteins is
arginine methylation. Methylation of arginine residues is crucial for a wide range of cellular …

Simple Summary Medulloblastoma is the most prevalent intracerebellar pediatric brain
tumor, accounting for approximately 20% of all childhood brain tumors and over 60% of …

Abstract Purpose of Review Adenoid cystic carcinoma (ACC) is a rare and heterogeneous
malignancy of secretory glands. Recurrence after curative-intent treatment is common, and …

The protein arginine methyltransferases (PRMTs) are involved in such biological processes
as transcription regulation, DNA repair, RNA splicing, and signal transduction, etc. In this …

Abstract H3K27-altered Diffuse Midline Glioma (DMG) is a universally fatal paediatric
brainstem tumour. The prevalent driver mutation H3K27M creates a unique epigenetic …