The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

Abundant data support a key role for the transcription factor nuclear factor-κB (NF-κB)
signaling pathway in controlling the initiation and progression of human cancer. NF-κB and …

Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug
research. A common approach is to infer signaling activity of pathways from gene …

Emerging evidence shows that the efficacy of chemotherapeutic drugs is reliant on their
capability to induce immunogenic cell death (ICD), thus transforming dying tumor cells into …

Importance of the field: Nuclear factor kappa B (NF-κB) is activated by a variety of cancer-
promoting agents. The reciprocal activation between NF-κB and inflammatory cytokines …

The transcription factor NF-κB and associated regulatory factors (including IκB kinase
subunits and the IκB family member Bcl-3) are strongly implicated in a variety of hematologic …

It has become increasingly clear that deregulation of the NF κ B signaling cascade is a
common underlying feature of many human ailments including cancers. The past two …

BAY 11‐7082 (BAY) is an inhibitor of κB kinase (IKK) that has pharmacological activities that
include anticancer, neuroprotective, and anti‐inflammatory effects. In this study, BAY …

Multiple drug resistance (MDR), defined as the ability of tumour cells to survive exposure to
many chemotherapeutic agents, is a major cause of treatment failure in human cancers. The …

The nuclear factor-κB (NF-κB) pathway is one of the most important cellular signal
transduction pathways involved in both physiologic processes and disease conditions. It …