Mass spectrometry plays a key role in relative quantitative comparisons of proteins in order
to understand their functional role in biological systems upon perturbation. In this review, we …

The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

Mass spectrometry (MS) has emerged at the forefront of quantitative proteomic techniques.
Liquid chromatography‐mass spectrometry (LC‐MS) can be used to determine abundances …

Tumor progression and dissemination critically depend on support from the tumor
microenvironment, the ensemble of cellular and acellular components surrounding and …

Over the past decade, chemical labeling with isobaric tandem mass tags, such as isobaric
tags for relative and absolute quantification reagents (iTRAQ) and tandem mass tag (TMT) …

Mass spectrometry (MS)-based proteomics have been increasingly implemented in various
disciplines of laboratory medicine to identify and quantify biomolecules in a variety of …

Background Celastrol (cel) was one of the earliest isolated and identified chemical
constituents of Tripterygium wilfordii Hook. f. Based on a cel probe (cel-p) that maintained …

The complexity of Alzheimer's disease (AD) and its long prodromal phase poses challenges
for early diagnosis and yet allows for the possibility of the development of disease modifying …

Recent advancements in mass spectrometry (MS) have revolutionized quantitative
proteomics, with multiplex isotope labeling emerging as a key strategy for enhancing …

Type 2 diabetes mellitus (T2DM) is one of the most common diseases of endocrine and
metabolic disorders, whose mechanism is still largely unknown. Fortunately, various “omics” …