It is now well established that the glial fibrillary acidic protein (GFAP) is the principal 8–9 nm
intermediate filament in mature astrocytes of the central nervous system (CNS). Over a …

Human neurological disorders such as Parkinson's disease, Huntington's disease,
amyotrophic lateral sclerosis (ALS), Alzheimer's disease, multiple sclerosis (MS), stroke, and …

Human neurodegenrative diseases such as P arkinson's disease (PD), H untington's
disease (HD), amyotrophic lateral sclerosis (ALS) and A lzheimer's disease (AD) are caused …

There are three main mechanisms of neuronal cell death which may act separately or
cooperatively to cause neurodegeneration. This lethal triplet of metabolic compromise …

We investigated the therapeutic potential of human bone marrow-derived mesenchymal
stem cells (hBM-MSCs) in Huntington's disease (HD) mouse models. Ten weeks after …

An animal model induced by striatal quinolinic acid (QA) injection shows ongoing striatal
degeneration mimicking Huntington's disease. To study the migratory ability and the …

Gene therapy for neurological disorder is currently an experimental concept. The goals for
clinical utilization are the relief of symptoms, slowing of disease progression, and correction …

Inoculation and growth conditions for the large‐scale expansion of mammalian neural stem
cells (NSC) have been determined. We examined suspension culture bioreactors of murine …

Several neurotrophic factors are known to induce neuroprotection in traumatic injuries to the
central nervous system (CNS). However, many neurotrophins are unable to attenuate cell …

The objective of the present study was to explore whether grafted immortalized neural stem
cells, genetically modified to secrete nerve growth factor (NGF), can ameliorate neuronal …