Methotrexate (MTX) is used as an anchor disease-modifying anti-rheumatic drugs
(DMARDs) in treating rheumatoid arthritis (RA) because of its potent efficacy and tolerability …

People are exposed to a number of environmental, occupational, and therapeutic toxic
agents which may be natural or man made. These hazardous substances may manifest as …

Silymarin (SLY) and naringin (NRG) are natural flavonoids that have been reported to have
many benefits and medicinal properties. The present study was designed to investigate the …

The current study was designed to investigate the beneficial role of diosmin, a biologically
active flavonoid, against methotrexate‐(MTX‐) induced hepatic, renal, and cardiac injuries in …

To investigate mechanisms by which thymoquinone (TQ) can prevent methotrexate‐(MTX‐)
induced hepatorenal toxicity, TQ (10 mg/kg) was administered orally for 10 days. In …

Doxorubicin (DXR) is one of the most important chemotherapeutic agent. However,
nephrotoxicity reduces its clinical utility in humans. The aim of the study was to investigate …

As a widely used anticancer and immunosuppressive agent, methotrexate (MTX) can induce
multiple adverse drug reactions (ADRs), such as gastrointestinal toxicity, the mechanisms …

Introduction In multiple studies, involvement of oxidative stress in the pathogenesis of
methotrexate (MTX)-mediated liver damage has been confirmed. Use of many drugs has …

Rheumatoid arthritis (RA) is a disabling autoimmune disease with invasive arthritis as the
main manifestation and synovitis as the basic pathological change, which can cause …

Curcumin has attracted much attention for medicinal purposes in wide range of illnesses
including cancer. In some studies, its efficacy is evaluated against chemotherapy and …