Protein S-acylation, the only fully reversible posttranslational lipid modification of proteins, is
emerging as a ubiquitous mechanism to control the properties and function of a diverse …

Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

Protein palmitoylation, a classical and common lipid modification, regulates diverse aspects
of neuronal protein trafficking and function. The reversible nature of palmitoylation provides …

Lipid rafts are liquid-ordered (lo) phase microdomains proposed to exist in biological
membranes. Rafts have been widely studied by isolating lo-phase detergent-resistant …

γ-Secretase is a promiscuous protease that cleaves bitopic membrane proteins within the
lipid bilayer. Elucidating both the mechanistic basis of γ-secretase proteolysis and the …

Named after the Sanskrit word netr, which means' one who guides', the netrin family of
secreted proteins provides migrational cues in the developing central nervous system …

Sphingolipid and cholesterol-rich liquid ordered lipid domains (lipid rafts) have been studied
in both eukaryotic cells and model membranes. However, while the coexistence of ordered …

The molecular code that controls synapse formation and maintenance in vivo has remained
quite sparse. Here, we identify that the secreted protein Adamtsl3 functions as critical …

Localization of the death receptor Fas to specialized membrane microdomains is crucial to
Fas‐mediated cell death signaling. Here, we report that the post‐translational modification of …

The intricate connections of the nervous system are established, in part, by elongating
axonal fibers that are directed by complex guidance systems to home in on their specific …