Super-enhancers (SEs) consist of multiple typical enhancers enriched at high density with
transcription factors, histone-modifying enzymes and cofactors. Oncogenic SEs promote …

Cancer immunotherapy has gained traction in recent years owing to remarkable tumor
clearance in some patients. Despite the notable success of immune checkpoint blockade …

Purpose: HOXB13 is an androgen receptor (AR) coregulator specifically expressed in cells
of prostatic lineage. We sought to associate circulating tumor cell (CTC) HOXB13 expression …

中国初诊的前列腺癌患者中40%~ 70% 已处于转移性疾病阶段, 而前列腺癌发生,
发展的时空异质性及独特的转移模式使得基于活检组织取材分析免疫标志物的方式困难重重 …

Super-enhancers (SEs) are regions of the genome that play a crucial regulatory role in gene
expression by promoting large-scale transcriptional responses in various cell types and …

Simple Summary Patients with symptomatic Benign Prostatic Hyperplasia (BPH) showed
upregulated gene expression of biological pathways associated with T cell activation and …

Metastasis remains the principal cause of cancer-related lethality despite advancements in
cancer treatment. Dysfunctional epigenetic alterations are crucial in the metastatic cascade …

Background Recent reports have uncovered a HOXB13 variant (X285K) predisposing to
prostate cancer in men of West African ancestry. The clinical relevance and protein function …

Homeobox 13 (HOXB13) is an oncogenic transcription factor that directly regulates
expression of folate hydrolase 1, which encodes prostate-specific membrane antigen …

Simple Summary A significant number of prostate cancers (PC) recur in patients despite
treatment with chemotherapy or radiotherapy. While HOXB13 contributes to resistance to …