The use of lipid-formulated RNA vaccines for cancer or COVID-19 is associated with dose-
limiting systemic inflammatory responses in humans that were not predicted from preclinical …

As a breakthrough immunotherapy, T cell bispecific antibodies (T-BsAbs) are a promising
antibody therapy for various kinds of cancer. In general, T-BsAbs have dual-binding …

Glioblastoma (GBM) is the most typical and aggressive form of primary brain tumor in adults,
with a poor prognosis. Successful glioma treatment is hampered by ineffective medication …

Although long non coding RNAs (lncRNAs) and circular RNAs (circRNAs) play important
roles in the pathogenesis of diseases, endometriosis related lncRNAs and circRNAs are still …

Preclinical and clinical studies demonstrate that T cell‐dependent bispecific antibodies
(TDBs) induce systemic changes in addition to tumor killing, leading to adverse events …

An insufficient quantity of functional T cells is a likely factor limiting the clinical activity of T-
cell bispecific antibodies, especially in solid tumor indications. We hypothesized that …

Genetic splice variants have become of central interest in recent years, as they play an
important role in different cancers. Little is known about splice variants in melanoma. Here …

Ovarian cancer (OC) is the most fatal, gynecological malignancy. Compared with advanced
ovarian cancer, the 5 year survival rate of early ovarian cancer is significantly improved, and …

High-grade serous ovarian cancers (HGSOC) represent the most common subtype of
ovarian malignancies. Due to the frequency of late-stage diagnosis and high rates of …

Excessive systemic inflammation is characteristic to various acute conditions including
sepsis, viral infections and immunotherapy-induced adverse events such as cytokine …