Tumors of nearly every origin activate the expression of genes normally restricted to
gametogenic cells. These genes encode proteins termed cancer/testis (CT) antigens, since …

Simple Summary The experimental/pathological observation of genome chaos (including
massive and large-scale translocations, chromothripsis, and polyploidy cancer cells) …

Cancer cells have many abnormal characteristics enabling tumors to grow, spread, and
avoid immunologic and therapeutic destruction. Central to this is the innate ability of …

Ovarian cancer remains the most fatal gynecologic malignancy worldwide due to delayed
diagnosis as well as recurrence and drug resistance. Thus, the development of new tumor …

Background Germ cell tumours are uniquely associated with the gametogenic tissues of
males and females. A feature of these cancers is that they can express genes that are …

Upon anticancer treatment, cancer cells can undergo cellular senescence, ie, the temporal
arrest of cell division, accompanied by polyploidization and subsequent amitotic divisions …

Simple Summary Many current cancer treatments also target healthy cells, leading to severe
side effects, including infertility. Alternative more cancer specific targets, not expressed in …

The cancer-testis gene MAEL is involved in the development and progression of bladder,
liver and colorectal cancers. However, its role in other cancers is unclear. By systematically …

Background Cancer/testis (CT) genes have expression normally restricted to the testis, but
become activated during oncogenesis, so they have excellent potential as cancer-specific …

The identification of cancer-specific biomolecules is of fundamental importance to the
development of diagnostic and/or prognostic markers, which may also serve as therapeutic …