5-Fluorouracil: a narrative review on the role of regulatory mechanisms in driving resistance to this chemotherapeutic agent

S Ghafouri-Fard, A Abak, F Tondro Anamag… - Frontiers in …, 2021 - frontiersin.org
5-fluorouracil (5-FU) is among the mostly administrated chemotherapeutic agents for a wide
variety of neoplasms. Non-coding RNAs have a central impact on the determination of the …

HERVs and cancer—A comprehensive review of the relationship of human endogenous retroviruses and human cancers

E Stricker, EC Peckham-Gregory, ME Scheurer - Biomedicines, 2023 - mdpi.com
Genomic instability and genetic mutations can lead to exhibition of several cancer hallmarks
in affected cells such as sustained proliferative signaling, evasion of growth suppression …

CRISPR/Cas9-mediated inactivation of miR-34a and miR-34b/c in HCT116 colorectal cancer cells: comprehensive characterization after exposure to 5-FU reveals …

Z Huang, M Kaller, H Hermeking - Cell Death & Differentiation, 2023 - nature.com
The miR-34a and miR-34b/c encoding genes represent direct targets of the p53 transcription
factor, and presumably mediate part of the tumor suppressive effects of p53. Here, we …

[HTML][HTML] Comprehensive landscape and future perspectives of long noncoding RNAs (lncRNAs) in colorectal cancer (CRC): Based on a bibliometric analysis

J He, W Wu - Non-coding RNA Research, 2023 - Elsevier
This review aimed to use bibliometric analysis to sort out, analyze and summarize the
knowledge foundation and hot topics in the field of long noncoding RNAs (lncRNAs) in …

Mechanisms of long non‐coding RNA function in colorectal cancer tumorigenesis

A Poursheikhani, MR Abbaszadegan… - Asia‐Pacific Journal …, 2021 - Wiley Online Library
Colorectal cancer (CRC) is one of the most common cancers globally. Although a variety of
CRC screening methods have been developed, many patients are diagnosed at advanced …

Knockdown of the long noncoding RNA PURPL induces apoptosis and sensitizes liver cancer cells to doxorubicin

T Berhane, A Holm, KT Karstensen, A Petri… - Scientific Reports, 2022 - nature.com
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with
increasing incidence in western countries. Most HCC patients have advanced cancer at the …

Genome‑wide analysis reveals the emerging roles of long non‑coding RNAs in cancer

X Ren - Oncology Letters, 2020 - spandidos-publications.com
Cancer is the most intractable human disease that is primarily caused by genetic alterations.
Recently, the general application of microarrays and high‑throughput sequencing …

LINC01021 Attenuates Expression and Affects Alternative Splicing of a Subset of p53-Regulated Genes

M Kaller, I Forné, A Imhof, H Hermeking - Cancers, 2024 - mdpi.com
Simple Summary Growing evidence indicates that p53-induced long noncoding (lnc) RNAs
constitute an elaborate regulatory network that mediates and/or modulates p53 function and …

The Prediction of Necroptosis‐Related lncRNAs in Prognosis and Anticancer Therapy of Colorectal Cancer

H Xiao, Q Pang, Y Wang, S Lai… - Analytical Cellular …, 2022 - Wiley Online Library
Background. Colorectal cancer is one of the most common gastrointestinal malignancies
globally. Necroptosis has been proved to play a role in the occurrence and development of …

Overexpression of PURPL and downregulation of NONHSAT062994 as potential biomarkers in gastric cancer

H Moridi, J Karimi, H Tavilani, I Khodadadi… - Life sciences, 2019 - Elsevier
Abstract Aims Long non-coding RNAs (LncRNAs) play central roles in the formation and
development of gastric cancer (GC). The aim of this study was to evaluate the expression of …