The healing bitterness of Gentiana lutea L., phytochemistry and biological activities: A systematic review

M Ponticelli, L Lela, M Moles, C Mangieri, D Bisaccia… - Phytochemistry, 2023 - Elsevier
Over many years, natural products have been a source of healing agents and have
exhibited beneficial uses for treating human diseases. The Gentiana genus is the biggest …

Natural monoterpenes as potential therapeutic agents against atherosclerosis

J Yang, C Zhong, J Yu - International Journal of Molecular Sciences, 2023 - mdpi.com
Traditional herbal medicines based on natural products play a pivotal role in preventing and
managing atherosclerotic diseases, which are among the leading causes of death globally …

Computational pharmacology and bioinformatics to explore the potential mechanism of Schisandra against atherosclerosis

H Duan, GJ Khan, L Shang, H Peng, W Hu… - Food and Chemical …, 2021 - Elsevier
The present study uses network pharmacology to study the potential mechanism of
Schisandra against atherosclerosis. Drug-disease targets were explored through the …

Amarogentin has protective effects against sepsis-induced brain injury via modulating the AMPK/SIRT1/NF-κB pathway

B Song, W Zhou - Brain Research Bulletin, 2022 - Elsevier
Amarogentin (AMA), a secoiridoid glycoside that is mainly derived from SwertiaandGentiana
roots, has been confirmed to exhibit antioxidative, tumor-suppressive and anti-diabetic …

Amarogentin from Gentiana rigescens Franch Exhibits Antiaging and Neuroprotective Effects through Antioxidative Stress

D Disasa, L Cheng, M Manzoor, Q Liu… - Oxidative medicine …, 2020 - Wiley Online Library
In the present study, the replicative lifespan assay of yeast was used to guide the isolation of
antiaging substance from Gentiana rigescens Franch, a traditional Chinese medicine. A …

Malvidin-3-O-arabinoside ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy

Y Li, Y Xu, J Xie, W Chen - Food & function, 2020 - pubs.rsc.org
Ethyl carbamate (EC) is an environmental toxin, commonly present in various fermented
foods and beverages, as well as tobacco and polluted ambient air. However, studies on the …

[HTML][HTML] Phytochemical characterization and anti-inflammatory activity of a water extract of Gentiana purpurea roots

L Zhang, ES Ulriksen, H Hoel, L Sandvik… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Gentiana purpurea was one of the most important
medicinal plants in Norway during the 18th and 19th centuries, and the roots were used …

Biologically active secoiridoids: A comprehensive update

Z Peng, J He, Y Cheng, J Xu… - Medicinal Research …, 2023 - Wiley Online Library
Secoiridoids are natural products of cyclopentane monoterpene derivatives that are formed
by splitting the rings of cyclomethene oxime compounds at C‐7 and C‐8, and only account …

Systems pharmacology‐based drug discovery and active mechanism of phlorotannins for type 2 diabetes mellitus by integrating network pharmacology and …

J Chen, P Li, S Ye, W Li, M Li… - Journal of Food …, 2022 - Wiley Online Library
Phlorotannins, polyphenolic compounds that exist only in brown algae, have an effect on
T2DM. However, the structure of phlorotannins is complex and diverse, and the complex role …

[HTML][HTML] Amarogentin inhibits vascular smooth muscle cell proliferation and migration and attenuates neointimal hyperplasia via AMPK activation

F Jia, R Ji, G Qiao, Z Sun, X Chen, Z Zhang - Biochimica et Biophysica Acta …, 2023 - Elsevier
Objectives Recent studies validated the expression of extraoral bitter taste receptors and
established the importance of regulatory functions that are associated with various cellular …