The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

The American Thoracic Society/European Respiratory Society jointly created a Task Force
on “Outcomes for COPD pharmacological trials: from lung function to biomarkers” to inform …

Rationale: Exacerbations of chronic obstructive pulmonary disease (COPD) are
heterogeneous with respect to inflammation and etiology. Objectives: Investigate biomarker …

Background: Patients with chronic obstructive pulmonary disease (COPD) are prone to
frequent exacerbations which are a significant cause of morbidity and mortality. Stable …

BACKGROUND Although it is presumed that exacerbations of chronic obstructive pulmonary
disease (COPD) are associated with increased airway inflammation, there is little …

Study objectives Patients with COPD experience lower airway and systemic inflammation,
and an accelerated decline in FEV 1. There is no evidence on whether this inflammation …

Background: Acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) are
a common cause of hospital admission. Many exacerbations are believed to be due to upper …

Relationships between high-resolution computed tomography (HRCT) findings in chronic
obstructive pulmonary disease (COPD) and bacterial colonization, airway inflammation, or …

High flow nasal cannula (HFNC) supportive therapy has emerged as a safe, useful therapy
in patients with respiratory failure, improving oxygenation and comfort. Recently several …

Chronic obstructive pulmonary disease (COPD) is characterized by an accelerated decline
in lung function and progressive airway inflammation. Bacteria have been isolated from the …