In the 30 years since the first report of parental imprinting in insulin-like growth factor 2 (Igf2)
knockout mouse models, we have learnt much about the structure of this protein, its role and …

Maternal-offspring interactions in mammals involve both cooperation and conflict. The fetus
has evolved ways to manipulate maternal physiology to enhance placental nutrient transfer …

Investigations of memory mechanisms have been, thus far, neuron centric, despite the brain
comprising diverse cell types. Using rats and mice, we assessed the cell-type-specific …

Type 1 Diabetes (T1D) is a chronic autoimmune disease characterized by a gradual
destruction of insulin-producing β-cells in the endocrine pancreas due to innate and specific …

In all eutherian mammals, growth of the fetus is dependent upon a functional placenta, but
whether and how the latter adapts to putative fetal signals is currently unknown. Here, we …

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Serine‐
arginine rich splicing factor 3 (SRSF3) plays a critical role in hepatocyte function and its loss …

Imprinting control region (ICR1) controls the expression of the Igf2 and H19 genes in a
parent-of-origin specific manner. Appropriate expression of the Igf2-H19 locus is …

Many studies support the link between parental obesity and the predisposition to develop
adult-onset metabolic syndromes that include obesity, high blood pressure, dyslipidemia …

Over the past few years, extensive efforts have been made to generate in-vitro pancreatic
micro-tissue, for disease modeling or cell replacement approaches in pancreatic related …

When exposed to nutrient excess and insulin resistance, pancreatic β-cells undergo
adaptive changes in order to maintain glucose homeostasis. The role that growth control …