The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …

Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Complex multicellular organisms require a coordinated response from multiple tissues to
maintain whole-body homeostasis in the face of energetic stressors such as fasting, cold …

Mitophagy is a type of autophagy that can selectively eliminate damaged and depolarized
mitochondria to maintain mitochondrial activity and cellular homeostasis. Several pathways …

Intermittent fasting (IF) has demonstrated extensive health benefits through the regulation of
fatty acid metabolism and modulation of the neuroimmune microenvironment, primarily via …

In contrast to the well-defined biological feedback loops controlling glucose, the
mechanisms by which the body responds to changes in fatty acid availability are less clearly …

Long-chain acyl-CoAs (LC-acyl-CoAs) are important intermediary metabolites and are also
thought to function as intracellular signaling molecules; however, the direct effects of LC-acyl …

Metabolic dysfunction-associated steatotic liver disease (MASLD) originates from a
homeostatic imbalance in hepatic lipid metabolism. Increased fat deposition in the liver of …

The simultaneous enhancement of lipophagy and mitochondrial biogenesis has emerged as
a promising strategy for lipid lowering. The transcription factor EB (TFEB) exhibits a dual …

Background AMP-activated protein kinase (AMPK) is an evolutionarily conserved regulator
of energy metabolism. AMPK is sensitive to acute perturbations to cellular energy status and …