Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals–a comprehensive review

L Padrela, MA Rodrigues, A Duarte, AMA Dias… - Advanced drug delivery …, 2018 - Elsevier
Low drug bioavailability, which is mostly a result of poor aqueous drug solubilities and of
inadequate drug dissolution rates, is one of the most significant challenges that …

[PDF][PDF] Pharmaceutical Cocrystals: An Overview.

S Kumar, A Nanda - Indian Journal of Pharmaceutical …, 2017 - pdfs.semanticscholar.org
Poor aqueous solubility and low oral bioavailability of an active pharmaceutical ingredient
are the major constraints during the development of new product. Various approaches have …

Engineering and manufacturing of pharmaceutical co-crystals: a review of solvent-free manufacturing technologies

SA Ross, DA Lamprou, D Douroumis - Chemical Communications, 2016 - pubs.rsc.org
Design and synthesis of pharmaceutical cocrystals have received great interest in recent
years. Cocrystallization of drug substances offers a tremendous opportunity for the …

Experimental cocrystal screening and solution based scale-up cocrystallization methods

M Malamatari, SA Ross, D Douroumis… - Advanced drug delivery …, 2017 - Elsevier
Cocrystals are crystalline single phase materials composed of two or more different
molecular and/or ionic compounds generally in a stoichiometric ratio which are neither …

Novel cocrystals of itraconazole: Insights from phase diagrams, formation thermodynamics and solubility

NA Vasilev, AO Surov, AP Voronin, KV Drozd… - International Journal of …, 2021 - Elsevier
In this work, the cocrystallization approach was applied to itraconazole (ITR), a very slightly
soluble triazole antifungal drug, which led to the formation of two new solid forms of ITR with …

Development of a pharmaceutical cocrystal with solution crystallization technology: Preparation, characterization, and evaluation of myricetin-proline cocrystals

M Liu, C Hong, Y Yao, H Shen, G Ji, G Li… - European Journal of …, 2016 - Elsevier
Myricetin shows low oral bioavailability (< 10%) in rats due to poor aqueous solubility,
although it has demonstrated various pharmacological activities such as those related to …

Comparing and quantifying the efficiency of cocrystal screening methods for Praziquantel

MD Charpentier, JJ Devogelaer, A Tijink… - Crystal Growth & …, 2022 - ACS Publications
Pharmaceutical cocrystals are highly interesting due to their effect on physicochemical
properties and their role in separation technologies, particularly for chiral molecules …

Mechanochemical synthesis of cocrystal: From mechanism to application

Y Xiao, C Wu, X Hu, K Chen, L Qi, P Cui… - Crystal Growth & …, 2023 - ACS Publications
Cocrystal engineering is gaining interest across various disciplines since it can effectively
tune the properties of solid substances via noncovalent synthesis by introducing new …

DSC as a screening tool for rapid co-crystal detection in binary mixtures of benzodiazepines with co-formers

P Saganowska, M Wesolowski - Journal of Thermal Analysis and …, 2018 - Springer
In recent years, co-crystals have been the subject of increasing interest within the
pharmaceutical industry because these new solid forms of active pharmaceutical ingredients …

Polymer-assisted aripiprazole–adipic acid cocrystals produced by hot melt extrusion techniques

A Butreddy, S Sarabu, S Bandari, N Dumpa… - Crystal growth & …, 2020 - ACS Publications
Pharmaceutical cocrystals offer a promising strategy to increase the solubility and
dissolution rate of poorly soluble drugs. However, their manufacturing process requires a …