The emerging scenario of the gut–brain axis: the therapeutic actions of the new actor kefir against neurodegenerative diseases

TMC Pereira, LZ Côco, AMM Ton, SS Meyrelles… - Antioxidants, 2021 - mdpi.com
The fact that millions of people worldwide suffer from Alzheimer's disease (AD) or
Parkinson's disease (PD), the two most prevalent neurodegenerative diseases (NDs), has …

Toxicity of polystyrene nanoplastics and zinc oxide to mice

FN Estrela, ATB Guimarães, AP da Costa Araújo… - Chemosphere, 2021 - Elsevier
The toxicity of zinc oxide (ZnO NPs) and polystyrene nanoplastics (PS NaPs) has been
tested in different animal models; however, knowledge about their impact on mice remains …

Increased ROS production and DNA damage in monocytes are biomarkers of aging and atherosclerosis

TA Jacinto, GS Meireles, AT Dias, R Aires, ML Porto… - Biological research, 2018 - Springer
Background New evidence demonstrates that aging and dyslipidemia are closely
associated with oxidative stress, DNA damage and apoptosis in some cells and …

Renoprotective, anti-oxidative and anti-apoptotic effects of oral low-dose quercetin in the C57BL/6J model of diabetic nephropathy

IBS Gomes, ML Porto, MCLFS Santos… - Lipids in Health and …, 2014 - Springer
Background Diabetic nephropathy (DN) is one of the major causes of end-stage renal
disease in diabetic patients. Increasing evidence from studies in the rodents has suggested …

Chronic Cadmium Exposure Accelerates the Development of Atherosclerosis and Induces Vascular Dysfunction in the Aorta of ApoE−/− Mice

TF Oliveira, PR Batista, MA Leal… - Biological trace element …, 2019 - Springer
Cadmium exposure is related to cardiovascular diseases, including hypertension,
atherosclerosis, increased oxidative stress, endothelial dysfunction, and specific …

Novel Therapeutic Targets for Phosphodiesterase 5 Inhibitors: current state-of-the-art on systemic arterial hypertension and atherosclerosis

EC Vasquez, AL Gava, JB Graceli… - Current …, 2016 - ingentaconnect.com
The usefulness of selective inhibitors of phosphodiesterase 5 (PDE5) is well known, first for
the treatment of male erectile dysfunction and more recently for pulmonary hypertension …

Reactive oxygen species contribute to dysfunction of bone marrow hematopoietic stem cells in aged C57BL/6 J mice

ML Porto, BP Rodrigues, TN Menezes… - Journal of Biomedical …, 2015 - Springer
Background Stem cells of intensely regenerative tissues are susceptible to cellular damage.
Although the response to this process in hematopoietic stem cells (HSCs) is crucial, the …

Dibutyl phthalate exposure disrupts the progression of meiotic prophase I by interfering with homologous recombination in fetal mouse oocytes

Z Tu, X Mu, X Chen, Y Geng, Y Zhang, Q Li, R Gao… - Environmental …, 2019 - Elsevier
Dibutyl phthalate (DBP), one of the most widely used plasticizers, is a known environmental
endocrine disruptor that impairs male and female fertility. In this study, oral administration of …

Chronic administration of the soluble, nonbacterial fraction of kefir attenuates lipid deposition in LDLr−/− mice

AF Santanna, PF Filete, EM Lima, ML Porto… - Nutrition, 2017 - Elsevier
Objectives Kefir is obtained by the action of acidic bacteria and yeasts that exist in symbiotic
association in kefir grains. Recently, this fermented milk drink has been recommended for …

Bisphenol A contamination in infant rats: Molecular, structural, and physiological cardiovascular changes and the protective role of kefir

AGF Friques, FDN Santos, DB Angeli, FAC Silva… - The Journal of …, 2020 - Elsevier
The effects of bisphenol A (BPA) contamination on the cardiovascular function still are not
clear. Here, we evaluated the vascular effects of BPA and the protective actions of kefir in …