Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response

T Fu, LJ Dai, SY Wu, Y Xiao, D Ma, YZ Jiang… - Journal of hematology & …, 2021 - Springer
Tumors are not only aggregates of malignant cells but also well-organized complex
ecosystems. The immunological components within tumors, termed the tumor immune …

Characteristics of the cancer stem cell niche and therapeutic strategies

F Ju, MM Atyah, N Horstmann, S Gul, R Vago… - Stem Cell Research & …, 2022 - Springer
Distinct regions harboring cancer stem cells (CSCs) have been identified within the
microenvironment of various tumors, and as in the case of their healthy counterparts, these …

Tumor microenvironment in gastric cancers

Y Oya, Y Hayakawa, K Koike - Cancer science, 2020 - Wiley Online Library
The tumor microenvironment favors the growth and expansion of cancer cells. Many cell
types are involved in the tumor microenvironment such as inflammatory cells, fibroblasts …

Molecular pathogenesis, targeted therapies, and future perspectives for gastric cancer

Y Zeng, RU Jin - Seminars in cancer biology, 2022 - Elsevier
Gastric cancer is a major source of global cancer mortality with limited treatment options and
poor patient survival. As our molecular understanding of gastric cancer improves, we are …

[HTML][HTML] Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling

Y Hayakawa, K Sakitani, M Konishi, S Asfaha… - Cancer cell, 2017 - cell.com
Within the gastrointestinal stem cell niche, nerves help to regulate both normal and
neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer …

The physiology of the gastric parietal cell

AC Engevik, I Kaji, JR Goldenring - Physiological reviews, 2020 - journals.physiology.org
Parietal cells are responsible for gastric acid secretion, which aids in the digestion of food,
absorption of minerals, and control of harmful bacteria. However, a fine balance of activators …

Metaplasia: tissue injury adaptation and a precursor to the dysplasia–cancer sequence

V Giroux, AK Rustgi - Nature Reviews Cancer, 2017 - nature.com
Metaplasia is the replacement of one differentiated somatic cell type with another
differentiated somatic cell type in the same tissue. Typically, metaplasia is triggered by …

Tumor endothelial cells accelerate tumor metastasis

N Maishi, K Hida - Cancer science, 2017 - Wiley Online Library
Tumor metastasis is the main cause of cancer‐related death. Understanding the molecular
mechanisms underlying tumor metastasis is crucial to control this fatal disease. Several …

WNT signaling in cancer immunosurveillance

L Galluzzi, S Spranger, E Fuchs, A López-Soto - Trends in cell biology, 2019 - cell.com
Deregulated WNT signaling has been shown to favor malignant transformation, tumor
progression, and resistance to conventional cancer therapy in a variety of preclinical and …

Cellular plasticity, reprogramming, and regeneration: metaplasia in the stomach and beyond

JR Goldenring, JC Mills - Gastroenterology, 2022 - Elsevier
The mucosa of the body of the stomach (ie, the gastric corpus) uses 2 overlapping, depth-
dependent mechanisms to respond to injury. Superficial injury heals via surface cells with …