The eukaryotic 5′ untranslated region (UTR) is critical for ribosome recruitment to the
messenger RNA (mRNA) and start codon choice and plays a major role in the control of …

In addition to the main, protein-coding, open reading frame (mORF), many eukaryotic
mRNAs contain upstream ORFs (uORFs) initiated at AUG or near-cognate codons residing …

This review summarizes our current understanding of the major pathway for the initiation
phase of protein synthesis in eukaryotic cells, with a focus on recent advances. We describe …

Although it was long thought that eukaryotic translation almost always initiates at an AUG
start codon, recent advancements in ribosome footprint mapping have revealed that non …

In eukaryotes, the translation initiation codon is generally identified by the scanning
mechanism, wherein every triplet in the messenger RNA leader is inspected for …

Translation initiation in eukaryotes is a highly regulated and complex stage of gene
expression. It requires the action of at least 12 initiation factors, many of which are known to …

COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which infected> 200 million people resulting in> 4 million deaths. However, temporal …

Translation initiation in eukaryotes is a complex and highly regulated process requiring the
action of at least 12 protein factors. The pathway is distinguished by the formation of a pre …

Regulation of gene expression is fundamental in establishing cellular diversity and a target
of natural selection. Untranslated mRNA regions (UTR s) are key mediators of post …

Recent proteogenomic studies revealed extensive translation outside of annotated protein
coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non …