Biomolecular damage induced by ionizing radiation: the direct and indirect effects of low-energy electrons on DNA

E Alizadeh, TM Orlando, L Sanche - Annual review of physical …, 2015 - annualreviews.org
Many experimental and theoretical advances have recently allowed the study of direct and
indirect effects of low-energy electrons (LEEs) on DNA damage. In an effort to explain how …

Comparisons between the Direct and Indirect Effect of 1.5 keV X-rays and 0–30 eV Electrons on DNA: Base Lesions, Stand Breaks, Cross-Links, and Cluster …

Y Gao, Y Dong, X Wang, W Su, P Cloutier… - The Journal of …, 2024 - ACS Publications
The interaction of low energy electrons (LEEs; 1–30 eV) with genomic material can induce
multiple types of damage that may cause the loss of genetic information, mutations, genome …

Strand breaks induced by very low energy electrons: Product analysis and mechanistic insight into the reaction with TpT

G Khorsandgolchin, L Sanche, P Cloutier… - Journal of the …, 2019 - ACS Publications
Numerous experimental studies show that 5–15 eV electrons induce strand breaks in DNA
at energies below the ionization threshold of DNA components. In this energy range, DNA …

Probing the vibrational spectroscopy of the deprotonated thymine radical by photodetachment and state-selective autodetachment photoelectron spectroscopy via …

DL Huang, HT Liu, CG Ning, GZ Zhu, LS Wang - Chemical Science, 2015 - pubs.rsc.org
Deprotonated thymine can exist in two different forms, depending on which of its two N sites
is deprotonated: N1 [T–H]− or N3 [T–H]−. Here we report a photodetachment study of the N1 …

Low-Energy Electron Generation for Biomolecular Damage Inquiry: Instrumentation and Methods

E Alizadeh, D Chakraborty, S Ptasińska - Biophysica, 2022 - mdpi.com
Technological advancement has produced a variety of instruments and methods to generate
electron beams that have greatly assisted in the extensive theoretical and experimental …

Transient anions in radiobiology and radiotherapy: From gaseous biomolecules to condensed organic and biomolecular solids

E Alizadeh, S Ptasinska, L Sanche - Radiation Effects in …, 2016 - books.google.com
This chapter focuses on the fundamental processes that govern interactions of low‐-energy
(1–30 eV) electrons with biological systems. These interactions have been investigated in …

Radiation-induced damage to cellular DNA: Chemical nature and mechanisms of lesion formation

J Cadet, JR Wagner - Radiation Physics and Chemistry, 2016 - Elsevier
This mini-review focuses on the recent identification of several novel radiation-induced
single and tandem modifications in cellular DNA. For this purpose accurate high …

[HTML][HTML] Oxygen Effect on 0–30 eV Electron Damage to DNA Under Different Hydration Levels: Base and Clustered Lesions, Strand Breaks and Crosslinks

Y Gao, X Wang, P Cloutier, Y Zheng, L Sanche - Molecules, 2024 - mdpi.com
Studies on radiosensitization of biological damage by O2 began about a century ago and it
remains one of the most significant subjects in radiobiology. It has been related to increased …

[PDF][PDF] Radiation damage to nucleoprotein complexes in macromolecular crystallography

C Bury, EF Garman, HM Ginn, RBG Ravelli… - Journal of …, 2015 - journals.iucr.org
Significant progress has been made in macromolecular crystallography over recent years in
both the understanding and mitigation of X-ray induced radiation damage when collecting …

The effect of 111In radionuclide distance and auger electron energy on direct induction of DNA double-strand breaks: a Monte Carlo study using Geant4 toolkit

B Piroozfar, G Raisali, B Alirezapour… - International journal of …, 2018 - Taylor & Francis
Purpose: In this study, the effect of 111In position and Auger electron energy on direct
induction of DSBs was investigated. Materials and methods: The Geant4-DNA simulation …