Reliable transmission of activity from nerve to muscle is necessary for the normal function of
the body. The term 'safety factor'refers to the ability of neuromuscular transmission to remain …

Neuromuscular junctions (NMJs) have long been studied as particularly accessible
examples of chemical synapses. Nonetheless, some important features of neuromuscular …

Myasthenia gravis is a paralytic disorder with autoantibodies against acetylcholine receptors
at the neuromuscular junction. A proportion of patients instead has antibodies against …

The ability to form synapses is one of the fundamental properties required by the
mammalian nervous system to generate network connectivity. Structural and functional …

Permanent removal of axonal input to postsynaptic cells helps shape the pattern of neuronal
connections in response to experience, but the process is poorly understood. Intracellular …

1. Rats were injected once every 48 h with alpha‐bungarotoxin (alpha BTX) for periods up to
6 weeks. Injections caused weakness of facial muscles which lasted about 8 h …

Dystrophin, the protein product of the gene responsible for X-linked muscular dystrophies,
shares structural features with the cytoskeletal proteins spectrin and α-actinin. Like spectrin …

1. Age changes in spontaneous and evoked transmitter release, in receptor number and in
ultrastructure at the neuromuscular junction were studied in the CBF‐1 mouse strain, which …

Huntington's disease (HD) is a neurodegenerative disorder with complex symptoms
dominated by progressive motor dysfunction. Skeletal muscle atrophy is common in HD …

1. At the rat neuromuscular junction, the postsynaptic folds and the voltage‐gated sodium
channels (VGSCs) within them are thought to amplify the effects of postsynaptic currents. In …