Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …

Cancer remains a serious health concern representing one of the leading causes of deaths
worldwide. The enzyme human carbonic anhydrase IX (hCA IX) is found to be over …

Human carbonic anhydrases (HCAs) are responsible for the pH control and sensing in our
body and constitute key components in the central pH paradigm connected to cancer …

Abstract Decaprenylphosphoryl-β-D-ribose-2′-epimerase (DprE1), a crucial enzyme in the
process of arabinogalactan and lipoarabinomannan biosynthesis, has become the target of …

HIV-1 infection impairs cellular cholesterol efflux by downmodulating the cholesterol
transporter ABCA1, leading to metabolic co-morbidities like cardio-vascular disease. The …

Objective To investigate the expression intensity of carbonic anhydrase IX (CA-IX) in bladder
urothelial carcinoma and its predictive value for the recurrence after transurethral resection …

Despite the availability of high resolution crystal structure of the catalytic domain of human
carbonic anhydrase IX (denoted as HCA IX-c), its solution structure and functional dynamics …

The crystal structure of human carbonic anhydrase (HCA) II bound to an inhibitor molecule,
6-hydroxy-2-thioxocoumarin (FC5), shows FC5 to be located in a hydrophobic pocket at the …

Solid tumors often exhibit hypoxia, a condition resulting from rapid tumor growth that
outpaces oxygen supply. This hypoxic environment promotes angiogenesis and enhances …

Interactions of a prototypical bile acid (cholic acid,'Ch') and its corresponding sodium salt
(sodium cholate,'NaCh') with a standard dietary β-glucan (β-G), bearing β-D-glucopyranose …