Therapeutic targets in lung tissue remodelling and fibrosis
Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets
JC Hewlett, JA Kropski, TS Blackwell - Matrix Biology, 2018 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic disease of the lung that is marked by
progressive decline in pulmonary function and ultimately respiratory failure. Genetic and …
progressive decline in pulmonary function and ultimately respiratory failure. Genetic and …
Epigenetic regulator miRNA pattern differences among SARS-CoV, SARS-CoV-2, and SARS-CoV-2 world-wide isolates delineated the mystery behind the epic …
A detailed understanding of the molecular mechanism of SARS-CoV-2 pathogenesis is still
elusive, and there is a need to address its deadly nature and to design effective …
elusive, and there is a need to address its deadly nature and to design effective …
ISM1 protects lung homeostasis via cell-surface GRP78-mediated alveolar macrophage apoptosis
TYW Lam, N Nguyen, HY Peh… - Proceedings of the …, 2022 - National Acad Sciences
Alveolar macrophages (AMs) are critical for lung immune defense and homeostasis. They
are orchestrators of chronic obstructive pulmonary disease (COPD), with their number …
are orchestrators of chronic obstructive pulmonary disease (COPD), with their number …
Inflammation, fibrosis and cancer: mechanisms, therapeutic options and challenges
Simple Summary Inflammation is like the proverbial double-edged sword. Controlled short-
term inflammation could be a protective response while uncontrolled inflammation sustains …
term inflammation could be a protective response while uncontrolled inflammation sustains …
Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications
B Mészáros, H Sámano-Sánchez… - Science …, 2021 - science.org
The first reported receptor for SARS-CoV-2 on host cells was the angiotensin-converting
enzyme 2 (ACE2). However, the viral spike protein also has an RGD motif, suggesting that …
enzyme 2 (ACE2). However, the viral spike protein also has an RGD motif, suggesting that …
Cyclic tailor-made amino acids in the design of modern pharmaceuticals
J Liu, J Han, K Izawa, T Sato, S White… - European Journal of …, 2020 - Elsevier
Tailor-made AAs are indispensable components of modern medicinal chemistry and are
becoming increasingly prominent in new drugs. In fact, about 30% of small-molecule …
becoming increasingly prominent in new drugs. In fact, about 30% of small-molecule …
Orthohantavirus pathogenesis and cell tropism
Orthohantaviruses are zoonotic viruses that are naturally maintained by persistent infection
in specific reservoir species. Although these viruses mainly circulate among rodents …
in specific reservoir species. Although these viruses mainly circulate among rodents …
SARS-CoV-2 attachment to host cells is possibly mediated via RGD-integrin interaction in a calcium-dependent manner and suggests pulmonary EDTA chelation …
TC Dakal - Immunobiology, 2021 - Elsevier
SARS-CoV-2 is a highly contagious virus that has caused serious health crisis world-wide
resulting into a pandemic situation. As per the literature, the SARS-CoV-2 is known to exploit …
resulting into a pandemic situation. As per the literature, the SARS-CoV-2 is known to exploit …
RGD‐binding integrins and TGF‐β in SARS‐CoV‐2 infections–novel targets to treat COVID‐19 patients?
I Carvacho, M Piesche - Clinical & Translational Immunology, 2021 - Wiley Online Library
The new coronavirus SARS‐CoV‐2 is a global pandemic and a severe public health crisis.
SARS‐CoV‐2 is highly contagious and shows high mortality rates, especially in elderly and …
SARS‐CoV‐2 is highly contagious and shows high mortality rates, especially in elderly and …