Synthetic cells in biomedical applications

W Sato, T Zajkowski, F Moser… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Synthetic cells are engineered vesicles that can mimic one or more salient features of life.
These features include directed localization, sense‐and‐respond behavior, gene …

Rational design of polymeric micelles for targeted therapeutic delivery

Y Zheng, Y Oz, Y Gu, N Ahamad, K Shariati… - Nano Today, 2024 - Elsevier
Polymeric micellar drug carriers have emerged as effective tools to enhance the solubility
and bioavailability of hydrophobic drugs. These micelles possess a nano size structure that …

Nanoparticle surface engineering with heparosan polysaccharide reduces serum protein adsorption and enhances cellular uptake

W Yang, L Wang, M Fang, V Sheth, Y Zhang… - Nano …, 2022 - ACS Publications
Nanoparticle modification with poly (ethylene glycol)(PEG) is a widely used surface
engineering strategy in nanomedicine. However, since the artificial PEG polymer may …

Controlling nanoparticle uptake in innate immune cells with heparosan polysaccharides

W Yang, AN Frickenstein, V Sheth, A Holden… - Nano …, 2022 - ACS Publications
We used heparosan (HEP) polysaccharides for controlling nanoparticle delivery to innate
immune cells. Our results show that HEP-coated nanoparticles were endocytosed in a time …

Glycosaminoglycans: Carriers and targets for tailored anti-cancer therapy

A Berdiaki, M Neagu, EM Giatagana, A Kuskov… - Biomolecules, 2021 - mdpi.com
The tumor microenvironment (TME) is composed of cancerous, non-cancerous, stromal, and
immune cells that are surrounded by the components of the extracellular matrix (ECM) …

[HTML][HTML] Bioengineered heparin: Advances in production technology

R Sultana, M Kamihira - Biotechnology Advances, 2024 - Elsevier
Heparin, a highly sulfated glycosaminoglycan, is considered an indispensable anticoagulant
with diverse therapeutic applications and has been a mainstay in medical practice for nearly …

[HTML][HTML] Tailored hyaluronic acid-based nanogels as theranostic boron delivery systems for boron neutron cancer therapy

S Coninx, G Kalot, A Godard, E Bodio, C Goze… - International Journal of …, 2022 - Elsevier
Boron-rich nanocarriers possess great potential for advanced boron neutron capture therapy
(BNCT) as an effective radiation treatment for invasive malignant tumors. If additionally, they …

Advancements in heparosan production through metabolic engineering andimproved fermentation

LL Sheng, YM Cai, Y Li, SL Huang, JZ Sheng - Carbohydrate Polymers, 2024 - Elsevier
Heparin is one of the most widely used natural drugs, and has been the preferred
anticoagulant and antithrombotic agent in the clinical setting for nearly a century. Heparin …

High density fermentation of probiotic E. coli Nissle 1917 towards heparosan production, characterization, and modification

P Datta, L Fu, P Brodfuerer, JS Dordick… - Applied Microbiology and …, 2021 - Springer
Heparosan is a naturally occurring non-sulfated glycosaminoglycan. Heparosan serves as
the substrate for chemoenzymatic synthesis of biopharmaceutically important heparan …

Reactive precursor particles as synthetic platform for the generation of functional nanoparticles, nanogels, and microgels

A Gruber, L Navarro, D Klinger - Advanced Materials Interfaces, 2020 - Wiley Online Library
Precise control of the chemical functionality of polymer nanoparticles is a key requirement in
tailoring their (dynamic) colloidal properties toward advanced applications. However, current …