Organ allotransplantation has now reached an impassable ceiling inherent to the limited
supply of human donor organs. In the United States, there are currently over 100,000 …

Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …

For many patients with terminal/advanced cardiac failure, heart transplantation is the most
effective, durable treatment option, and offers the best prospects for a high quality of life. The …

Seriously compromised function of some organs can only be restored by transplantation.
Due to the shortage of human donors, the need to find another source of organs is of primary …

Natural killer (NK) cells play an important role in immune rejection in solid organ
transplantation. To mitigate human NK cell activation in xenotransplantation, introducing …

End-stage organ failure can result from various preexisting conditions and occurs in patients
of all ages, and organ transplantation remains its only treatment. In recent years, extensive …

Background Antibody-mediated rejection is a major cause of graft injury and contributes to
failure of pig xenografts in nonhuman primates (NHPs). Most 'natural'or elicited antibodies …

Pig organ xenotransplantation offers a solution to the shortage of deceased human organs
for transplantation. The pathobiological response to a pig xenograft is complex, involving …

Heart transplantation is the only long-lasting lifesaving option for patients with terminal
cardiac failure. The number of available human organs is however far below the actual …

Natural preformed and de novo antibodies against pig antigens are a major cause of pig
xenograft rejection in nonhuman primates (NHPs). In vivo studies in pig-to-NHP models are …